Renee Risingsong Selected Research

LG 100268

1/2016	The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
11/2010	Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
12/2009	Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
7/2008	Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
5/2008	The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.
10/2006	The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer.
5/2004	The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer.
10/2002	Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.

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Renee Risingsong Research Topics

Disease

15	Neoplasms (Cancer) 01/2016 - 07/2003
10	Carcinogenesis 01/2016 - 10/2007
9	Breast Neoplasms (Breast Cancer) 07/2014 - 10/2002
7	Lung Neoplasms (Lung Cancer) 01/2016 - 07/2006
4	Inflammation (Inflammations) 01/2016 - 10/2002
2	Carcinoma (Carcinomatosis) 12/2009 - 03/2007
2	Leukemia 08/2008 - 07/2003
1	Neuroinflammatory Diseases 07/2011
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 07/2011
1	Pathologic Processes 07/2011
1	Mitochondrial Diseases (Mitochondrial Disease) 07/2011
1	Pancreatic Neoplasms (Pancreatic Cancer) 11/2010
1	Adenocarcinoma of Lung 12/2009
1	Parkinson Disease (Parkinson's Disease) 06/2009
1	Neuroblastoma 06/2009
1	Huntington Disease (Huntington's Disease) 06/2009
1	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2009
1	Hyperplasia 05/2008
1	Adenocarcinoma 03/2007
1	Hepatocellular Carcinoma (Hepatoma) 03/2005
1	Melanoma (Melanoma, Malignant) 07/2003

Drug/Important Bio-Agent (IBA)

13	TriterpenesIBA 07/2015 - 07/2003
8	LG 100268IBA 01/2016 - 10/2002
8	bardoxolone methylIBA 07/2015 - 03/2007
8	bardoxoloneIBA 07/2015 - 07/2003
6	CarcinogensIBA 01/2016 - 10/2002
6	Estrogen ReceptorsIBA 01/2013 - 05/2004
5	vinyl carbamateIBA 01/2016 - 03/2007
5	AcidsIBA 05/2012 - 03/2007
4	EstersIBA 05/2012 - 03/2007
3	oleananeIBA 07/2015 - 12/2009
3	Pharmaceutical PreparationsIBA 07/2015 - 05/2004
3	2- cyano- 3,12- dioxooleana- 1,9(11)- dien- 28- oic acid ethyl amideIBA 11/2010 - 03/2007
3	Proteins (Proteins, Gene)FDA Link 12/2009 - 07/2007
3	LY 353381 (LY353381)IBA 10/2006 - 10/2002
3	Selective Estrogen Receptor Modulators (SERM)IBA 10/2006 - 10/2002
2	Histone Deacetylase InhibitorsIBA 01/2016 - 01/2013
2	Vorinostat FDA Link 01/2016 - 01/2013
2	1- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazoleIBA 07/2015 - 07/2003
2	Drug CombinationsIBA 01/2013 - 10/2006
2	ChemokinesIBA 01/2013 - 05/2012
2	Cyclin D1IBA 05/2012 - 01/2012
2	ErbB Receptors (EGF Receptor)IBA 05/2012 - 05/2008
2	Neuroprotective AgentsIBA 07/2011 - 06/2009
2	LG 268IBA 11/2010 - 05/2008
2	Synthetic DrugsIBA 11/2010 - 12/2009
2	AGN 194204IBA 12/2009 - 10/2007
2	EnzymesIBA 08/2008 - 07/2007
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 08/2008 - 07/2007
2	AmidesIBA 05/2008 - 03/2007
2	Transcription Factors (Transcription Factor)IBA 03/2007 - 07/2006
1	7- (2- (2,2- difluoroethoxy)- 3,5- di- tert- butylbenzene)- 3- methylocta- 2,4,6- trienoic acidIBA 01/2016
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2016
1	Carboplatin (JM8)FDA LinkGeneric 01/2016
1	Dimethyl FumarateIBA 07/2015
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 07/2014
1	veliparibIBA 07/2014
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 07/2014
1	olaparibIBA 07/2014
1	Macrophage Colony-Stimulating FactorIBA 01/2013
1	A 7 (A-7)IBA 01/2013
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2012
1	Oncogene Proteins (Oncogene Protein)IBA 05/2012
1	(2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oic acid) trifluoroethylamideIBA 07/2011
1	NF-E2-Related Factor 2IBA 07/2011
1	Gemcitabine FDA Link 11/2010
1	AflatoxinsIBA 08/2008
1	TBE 31IBA 08/2008
1	Interleukin-6 (Interleukin 6)IBA 07/2008
1	Retinoid X Receptors (Retinoid X Receptor)IBA 05/2008
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2008
1	Biological ProductsIBA 05/2008
1	LigandsIBA 05/2008
1	Betulinic AcidIBA 07/2007
1	Nitric Oxide Synthase (NO Synthase)IBA 03/2007
1	Heme Oxygenase-1IBA 03/2007
1	ritetroniumIBA 10/2006
1	quinone (benzoquinone)IBA 03/2005
1	NAD (NADH)IBA 03/2005
1	Oxidoreductases (Dehydrogenase)IBA 03/2005
1	Sulfhydryl Compounds (Thiols)IBA 03/2005
1	Transforming Growth Factor beta (TGF-beta)IBA 05/2004
1	Interferon-gamma (Interferon, gamma)IBA 10/2002
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2002
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 10/2002

Therapy/Procedure

4	Chemoprevention 07/2014 - 08/2008
1	Therapeutics 07/2015
1	Drug Therapy (Chemotherapy) 08/2008